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Altered ileum epithelial and immune cell profiles in the intestine of patients with MS.

ABSTRACT: The intestinal epithelium plays a critical role in immune–microbiota interactions, yet its contribution to systemic autoimmunity remains unclear. Here, we identify intestinal epithelial cells (IECs) as key initiators of experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis (MS). In MS patients, IECs upregulate antigen presentation–related genes and associate with increased intestinal Th17 cell accumulation.

ORGANISM(S): Homo sapiens

PROVIDER: GSE315728 | GEO | 2026/02/24

REPOSITORIES: GEO

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