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Toll signalling controls intestinal regeneration in Drosophila

ABSTRACT: This study is part of a manuscript approved for publication in Development (Cambridge UK) showing that the Toll pathway in Drosophila is necessary and sufficient for intestinal stem cell mitosis following infection and under homeostatic conditions. Chronic activation of Toll using a gain of function mutation (Toll10b) induces intestinal stem cell proliferation while blocking differentiation of enteroblasts to enterocytes. Thus, the intestinal tissue becomes replete with progenitor cells. The RNA-seq data deposited here are on whole guts of 20-day old flies where Toll has been activated in intestinal progenitor cells post-developmentally (in adults) from day 1 using the GAL4/GAL80ts system.

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE315850 | GEO | 2026/01/15

REPOSITORIES: GEO

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