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Let-7 and lin-46 are the essential targets of the LIN28 RNA-binding protein in temporal patterning [mRNA-seq RIPseq]

ABSTRACT: We identified 581 transcripts enriched ≥2-fold for LIN-28 binding in L1 animals.

ORGANISM(S): Caenorhabditis elegans

PROVIDER: GSE315949 | GEO | 2026/06/10

REPOSITORIES: GEO

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let-7 and lin-46 are the essential targets of the LIN28 RNA-binding protein in temporal patterning [mRNA-seq TC1]

Project description:We examined gene expression changes using mRNA-seq in two different lin-28 mutant strains, lin-28(n719) and lin-28(xe192). Although both are considered genetic null mutants, their expression profiles differ substantially: lin-28(n719) (a point mutation affecting a splice site) shows many more dysregulated genes than lin-28(xe192) (a deletion of the entire lin-28 locus).

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let-7 and lin-46 are the essential targets of the LIN28 RNA-binding protein in temporal patterning [mRNA-seq TC5]

Project description:We examined mRNA levels using mRNA-seq in wild-type (N2), lin-28 mutant animals (HW2705) and animals that have the single GGAG motif (i.e. the putative LIN-28 binding motif) in the lin-46 5'UTR mutated to CTCC (HW3531).

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let-7 and lin-46 are the essential targets of the LIN28 RNA-binding protein in temporal patterning [mRNA-seq TC2]

Project description:We examined mRNA levels in wild-type and lin-28(xe192) animals throughout postembryonic development (0-44 h) with hourly resolution. Samples collected at 3 to 6 hours of development were used as one of the three biological replicates used to determine differentially expressed genes in lin-28(xe192) animals.

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let-7 and lin-46 are the essential targets of the LIN28 RNA-binding protein in temporal patterning [smallRNA-seq TC2]

Project description:We examined the levels of small RNAs in wild-type and lin-28(xe192) animals throughout postembryonic development (0-44 h) with hourly resolution. The first time points (0h to 23h) of this experiment were published previously and are accessible under the accession GSE245900 (Nahar et al. 2024). In that previous submission, all samples were sequenced twice to increase coverage (two fastq files per sample on SRA). The new samples published here (24h-44h) were only sequenced once and are thus compatible with the first sequencing round of GSE245900. While in this submission only the raw data of the new samples (24h-44h) are published, we included the time points 0h to 23h (considering only the first sequencing run, see above) in the processed data files. Due to the differences in sequencing depths between the two submissions, the intensity values for time points 0h to 23h are not identical even though they originate from the same biological samples.

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let-7 and lin-46 are the essential targets of the LIN28 RNA-binding protein in temporal patterning

Project description:This SuperSeries is composed of the SubSeries listed below.

2026-06-09 | GSE315957 | GEO

Effect of lin-28 and lin-46 on miRNA profile in late L1 stage Caenorhabditis elegans

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2012-02-09 | E-GEOD-35634 | biostudies-arrayexpress