Gsx2 Regulates Oligodendrocyte Precursor Formation in the Zebrafish Spinal Cord

ABSTRACT: In the spinal cord, neural progenitor cells (NPCs) of the pMN domain produce neurons in early development followed by oligodendrocytee precursor cells (OPCs), which subsequently differentiate as oligodendrocytes (OLs), the myelinating glia of the central nervous system. The mechanisms that specify neural progenitor cells to the OL lineage are not yet well understood. Using zebrafish, we combined single-cell Multi-omics and in vivo genetic approaches to identify gsx2 as a regulator of OPC specification.

ORGANISM(S): Danio rerio

PROVIDER: GSE316142 | GEO | 2026/01/12

REPOSITORIES: GEO