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Oxidative Stress-Induced Immunogenic Cell Death Enhances Whole-Cell Vaccine Efficacy in a Syngeneic Pancreatic Cancer Model

ABSTRACT: RNA sequencing was performed to characterize transcriptional changes induced by sub-lethal oxidative stress in murine pancreatic cancer cells. Panc02 cells were exposed to low-dose hydrogen peroxide and compared with untreated controls. Differential gene expression analysis revealed extensive transcriptomic remodeling, including induction of stress-response programs, inflammatory and antiviral signaling pathways, chemokines involved in immune cell recruitment, and components of the MHC class I antigen presentation machinery. These data define the RNA-level response of pancreatic cancer cells to oxidative stress and provide insight into mechanisms by which stress conditions enhance tumor cell immunogenicity.

ORGANISM(S): Mus musculus

PROVIDER: GSE316213 | GEO | 2026/01/15

REPOSITORIES: GEO

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