Pharmaco-behavioral Profiling Identifies Suppressors of Autism Gene-Associated Phenotypes in Zebrafish
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ABSTRACT: In this study, we establish a pharmaco-behavioral database of behavioral signatures of 520 U.S. FDA-approved drugs using high-throughput assays of basic sensory processing and arousal behaviors in larval zebrafish and define highly conserved effects of common psychotropic medication targets. By leveraging the behavioral profiles of nine large-effect ASD gene mutants, we identify enrichment of pharmacological mechanisms that anti-correlate with subgroups of ASD genes informed by a precision medicine approach.
ORGANISM(S): Danio rerio Homo sapiens
PROVIDER: GSE316340 | GEO | 2026/03/18
REPOSITORIES: GEO
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