Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptomic profiling of MCF-7 breast cancer cells post HOXB2 knockdown

ABSTRACT: Application of Next-generation sequencing technology to identify genes modulated by HOXB2 depletion in MCF-7 cells

ORGANISM(S): Homo sapiens

PROVIDER: GSE316581 | GEO | 2026/02/01

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Transcriptomic profiling of MCF-7 breast cancer cells treated with Karanjin

Project description:Application of next generation sequencing (NGS) technology to identify karanjin-modulated genes in MCF-7 breast cancer cells

2022-08-30 | GSE183913 | GEO

Transcriptomic profiling of MCF-7 breast cancer cells treated with G1, a G-protein coupled estrogen receptor (GPER1) agonist

Project description:Application of next generation sequencing (NGS) technology to identify G1-modulated genes in MCF-7 breast cancer cells

2021-11-27 | GSE188706 | GEO

Genome-wide effects of enterolactone on gene expression in MCF-7 cells

Project description:Application of next generation sequencing technology to identify genes modulated by enterolactone in MCF-7 cells

2023-01-06 | GSE216876 | GEO

Transcriptomic profiling of MCF-7 breast cancer cells post HOXB2 knockdown

Project description:Transcriptomic profiling of MCF-7 breast cancer cells post HOXB2 knockdown

| PRJNA1403421 | ENA

Genome-wide effects of Karanjin on gene expression in T47D breast cancer cells

Project description:Application of next generation sequencing technology (RNA-seq) to identify genes modulated by Karanjin in T47D cells

2023-12-31 | GSE233159 | GEO

The effects of Trichinella spiralis tropomyosin on breast cancer MCF-7 cells

Project description:The excretory-secretory proteins (ESPs) of Trichinella spiralis (T. spiralis) muscle larvae have been confirmed to exert antitumor effects by modulating host immune responses or directly acting on tumor cells. Our research group previously identified that the ESPs of T. spiralis muscle larvae contain multiple proteins potentially related to antitumor activity, among which tropomyosin (TM) has attracted our attention. This study aims to introduce TM from Trichinella spiralis (T. spiralis TM) into breast cancer MCF-7 cells via transfection technology. Furthermore, we investigated the impact of T. spiralis TM on the gene expression profile of MCF-7 cells through transcriptomics. Finally, the study systematically evaluated its regulatory effects on apoptosis, proliferation, and migration. We are the first to comprehensively evaluated the anticancer effects of T. spiralis TM on MCF-7 breast cancer cells. Our findings showed that T. spiralis TM increases apoptosis by activating the mitochondrial-mediated apoptosis pathway and inhibits cell migration and proliferation by downregulating the expression of important hub genes, including PRKACA, CDK3, VPS35, and BCAR1. These findings provide a novel theoretical basis for the application of molecules linked to Trichinella in tumor therapy and support for potential new targets.

2025-09-02 | GSE306260 | GEO

miRNA expression data in MCF-7 breast cancer Cell line post BCAS2 and FST knockdown

Project description:Previously, we have confirmed the tumor suppressive role of Estrogen Related Receptor β (ERRβ) in breast cancer by modulation of ER transcriptional activities on Breast Cancer Amplified Sequence 2 (BCAS2) and Follistatin(FST).In the mentioned study, we proved downregulation of Cyclin D1 by BCAS2.In the previous report, we have also proved downregulation of FST by BCAS2 through inhibition of β-catenin/TCF-4 complex recruitment on FST promoter. Interestingly, Cyclin D1 induction by FST has been also reported by a different group.Recently, Cyclin D1 expression has been found to be associated with DICER1 induction. Hence it may be speculated, that a part of miRNA population, which involves Dicer for processing, is regulated by BCAS2. And it is also possible, that FST may oppose the effect of BCAS2 on those Dicer-processed miRNAs.This Dicer-regulation by Cyclin D1was reported in Luminal A type of breast cancer. Hence, we chose MCF-7 breast cancer cells for miRNA profiling post knocking down BCAS2 and FST.

2017-10-31 | GSE89390 | GEO

Expression profiling of breast cancer cell lines MCF-7 and MCF-7R4

Project description:Human breast cancer cell line MCF-7 is usually sensitive to chemotherapy drug BMS-554417, an insulin receptor (IR) and insulin-like growth factor receptor (IGFR) inhibitor. However, through step-wise increase in BMS-554417 doses in culture media, we were able able to screen and select a single MCF-7 clone that is BMS-554417 resistant. It is cross resistant to BMS-536924. This new line of MCF-7 cells was named as MCF-7R4. The transcriptome profiling of both MCF-7 and MCF-7R4 was performed using Affymetrix HG-U133 plus2.0 GeneChip arrays.

2009-11-06 | GSE18912 | GEO

Expression data from CtBP knockdown MCF-7 cells

Project description:CtBP is a global co-repressor by serving as transcriptional factor in multiple pathways. CtBP functioned as transcriptional factor by recruiting other cofactors such as G9a, HDAC1 and PcG proteins. CtBP is found to be over enriched in several type of tumor samples. To dipict the role of CtBP in globally regulating gene expression, we applied gene microarray technology to find out what subgroups of genes are mainly affected. 6 MCF-7 cell samples, 3 with CtBP knockdown and 3 with control knock down.

2013-03-20 | E-GEOD-36529 | biostudies-arrayexpress