Bulk RNA sequencing of canine oral tumor samples (CAA, COSCC).

ABSTRACT: Canine acanthomatous ameloblastoma (CAA) is a locally invasive benign oral neoplasm. Clinically, differentiating CAA from canine oral squamous cell carcinoma (COSCC) has proven to be difficult as they share many clinical, radiological, and histological features. Molecularly, even though they both have an overactive MAPK pathway in comparison to healthy gingiva tissue, their mutational landscape is distinct. Bulk RNA sequencing (RNA-seq) has uncovered pronounced differences between CAA and COSCC in programs related to, among others, hypoxia, PI3K-AKT signaling, and cell proliferation.

ORGANISM(S): Canis lupus familiaris

PROVIDER: GSE317244 | GEO | 2026/05/22

REPOSITORIES: GEO