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Expression analysis of G9C8 clone and NOD.G9C8 tg CTLs

ABSTRACT: Diabetogenic CD8+ G9C8 clone cells and the T cells from a transgenic mouse bearing the same TCR as the clone, displayed differences in their ability to induce disease in vivo.Microarray analysis was done to identify the molecular basis for such differences between the two sets of CD8 T cells. Microarray analysis was done to identify the molecular basis for such differences between the two sets of CD8 T cells

ORGANISM(S): Mus musculus

PROVIDER: GSE31726 | GEO | 2012/12/04

SECONDARY ACCESSION(S): PRJNA145355

REPOSITORIES: GEO

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Expression analysis of G9C8 clone and NOD.G9C8 tg CTLs

Project description:Diabetogenic CD8+ G9C8 clone cells and the T cells from a transgenic mouse bearing the same TCR as the clone, displayed differences in their ability to induce disease in vivo.Microarray analysis was done to identify the molecular basis for such differences between the two sets of CD8 T cells. Microarray analysis was done to identify the molecular basis for such differences between the two sets of CD8 T cells 3 vials of frozen G9C8 clone cells and spleen cells from 2 NOD.G9C8 transgenic mice were similarly peptide stimulated for 3 days and rested in IL2 for 2 days in order to obtain uniformly activated cells for analysis.

2012-12-04 | E-GEOD-31726 | biostudies-arrayexpress

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Project description:Just as animal monozygotic twins can experience different environmental conditions by being reared apart, individual genetically-identical trees of the genus Populus can also be exposed to contrasting environmental conditions by being grown in different locations. As such, clonally-propagated Populus trees provide an opportunity to interrogate the impact of individual environmental history on current response to environmental stimuli. To test the hypothesis that current responses to an environmental stimulus, drought, are contingent on environmental history, the transcriptome-level drought responses of three economically important hybrid genotypes: DN34 (Populus deltoides x P. nigra); Walker (P. deltoides var. occidentalis x (P. laurifolia x P. nigra)); and, Okanese (‘Walker’ x (P. laurifolia x P. nigra)) derived from two different locations were compared. Strikingly, differences in transcript abundance patterns in response to drought were based on differences in geographic origin of clones for two of the three genotypes. This observation was most pronounced for the genotypes with the longest time since establishment and last common propagation. Differences in genome-wide DNA methylation paralleled the transcriptome level trends, where the clones with the most divergent transcriptomes and clone history had the most marked differences in the extent of total DNA methylation, suggesting an epigenetic basis for the clone-history-dependent transcriptome divergence. The data provide insights into the interplay between genotype and environment in the ecologically and economically important Populus genus, with implications for both the industrial application of Populus trees, and the evolution and persistence of these important tree species.

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Clone History Shapes Populus Drought Responses

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10X single-cell RNASeq profiling of control or Ptpn2-null P14 CD8+ T-cells from mice chronically infected with LCMV Clone 13

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