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CSN3 promotes gastric cancer invasion and is associated with immune infiltration via activating NOD/TLR pathways

ABSTRACT: We found that CSN3 is highly expressed in gastric cancer and is associated with advanced tumor stage, lymph node metastasis, and poor prognosis. Functional assays showed that CSN3 promotes proliferation and migration while inhibiting apoptosis in GC cells. RNA-sequencing revealed that CSN3 overexpression predominantly activates innate immune–related pathways, particularly the NOD-like receptor and Toll-like receptor signaling pathways, suggesting a role for CSN3 in inflammatory and immune remodeling of the tumor microenvironment. Consistently, CSN3 expression was positively correlated with B-cell and CD8⁺ T-cell infiltration, indicating that CSN3-driven transcriptional programs may link tumor aggressiveness with immune microenvironment alterations.

ORGANISM(S): Homo sapiens

PROVIDER: GSE317661 | GEO | 2026/02/01

REPOSITORIES: GEO

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