Influence of gut microbiota on oral drug absorption and metabolism

ABSTRACT: Gut microbiota are known to influence oral drug disposition, yet the specific host pathways they affect remain poorly characterized. This study provides a transcriptome-wide characterization of how physiological gut microbiota regulate the expression of intestinal transporters, phase I and phase II metabolic enzymes, and barrier machinery relevant to oral drug disposition. By identifying microbiota-responsive processes, this work defines the scope of inter-individual variability attributable to gut microbial effects.

ORGANISM(S): Mus musculus

PROVIDER: GSE317716 | GEO | 2026/01/31

REPOSITORIES: GEO