PD-1 signaling and PD-1 blockade-mediated tumor control are established at microvillar T cell contacts

ABSTRACT: To investigate the differences between nivolumab_mIgG1 and nivolumab_mIgG1_D265A, and to identify the context in which antibody agonism might impact therapy, we employed a single-cell RNA sequencing approach using 10x Genomics to study the immune populations of tumors, and draining lymph nodes (dLN), and non-draining lymph nodes (non-dLN).

ORGANISM(S): Mus musculus

PROVIDER: GSE317930 | GEO | 2026/03/25

REPOSITORIES: GEO