Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gene expression profiles of NSCLC tumors

ABSTRACT: A custom microarray was used to measure the gene expression of NSCLC tumors. This represents a subset of samples which also have matched DNA copy number profiles from array CGH experiments

ORGANISM(S): Homo sapiens

PROVIDER: GSE31799 | GEO | 2011/09/12

SECONDARY ACCESSION(S): PRJNA155047

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Gene expression profiles of NSCLC tumors

Project description:A custom microarray was used to measure the gene expression of NSCLC tumors. This represents a subset of samples which also have matched DNA copy number profiles from array CGH experiments 49 microdissected NSCLC tumor samples

2011-09-11 | E-GEOD-31799 | biostudies-arrayexpress

DNA copy number profiles of NSCLC tumors

Project description:Whole genome tiling path array CGH was used to measure the copy number profiles of 271 NSCLC tumors

2011-09-12 | GSE31798 | GEO

DNA copy number profiles of NSCLC tumors

Project description:Whole genome tiling path array CGH was used to measure the copy number profiles of 271 NSCLC tumors 271 microdissected NSCLC tumors

2011-09-11 | E-GEOD-31798 | biostudies-arrayexpress

Affymetrix SNP array data for NSCLC samples

Project description:Non-small cell lung cancer (NSCLC) presents a notoriously genomically unstable cancer type, with numerous large scale and focal genomic aberrations resulting in gene copy number variations across the whole genome. The relations of these gene copy number changes to subsequent mRNA levels are only fragmentarily understood. The aim of this study was an integrated analysis of gene copy number changes and corresponding gene expression in a large clinically annotated NSCLC patient cohort. Fresh frozen tumor sample from 190 resected NSCLC patients were subjected to SNP arrays and gene expression array analysis resulting 39788 tested copy number/ RNA expression pairs. Correlation analysis using an externally centered correlation coefficient (ECCC) revealed that gene expression of 19058 genes was significantly influenced by gene copy number changes (FDR < 0.05). However, only 440 probe sets demonstrated high correlations (ECCC > 0.7) that were mostly due to few cases with high gene copy number gains. These gene copy number dependent genes were clustered in only few chromosomal hot spot regions and classical oncogenes (e.g. EGFR, MDM2, KRAS) are overrepresented among these genes. In a meta-analysis, including 1585 NSCLC patients, gene expression levels from 70 of 440 (16%) gene-copy-number-dependent genes were associated with survival. In conclusion, the genome-wide analysis indicates that gene copy number aberrations influence directly gene expression levels in a distinct subset of genes. The concrete illustration of these molecular relations help to interpret the impact of gene copy number changes and may serve as starting points to identify new cancer drivers in NSCLC.

2016-08-31 | GSE76730 | GEO

Gene expression profiles of NSCLC tumors

Project description: Not available

| S-ECPF-GEOD-31799 | biostudies-other

Identification of a Four-lncRNA Signature Predicting Prognosis of Patients with NSCLC

Project description:LncRNA expression profiles were sucessfully contructed in 370 patients with NSCLC and 198 corresponding adjacent noncancerous tissues using a custom microarray containing probes for 2412 lncRNAs and an outcome prediction of lncRNA signature was successfully identified for predicting prognosis in NSCLC.

2020-08-31 | GSE143018 | GEO

The prognostic and predictive value of a three-microRNA-based classifier in NSCLC

Project description:MicroRNA expression profiles were sucessfully contructed in 397 patients with NSCLC and 151 corresponding adjacent noncancerous tissues using a custom microarray containing probes for 1888 miRNAs and an outcome prediction of miRNA signature was successfully identified for predicting prognosis in NSCLC.

2017-08-22 | GSE53882 | GEO

DNA copy number and gene expression profiles of resected non-small cell lung cancer tumors

Project description:This SuperSeries is composed of the following subset Series: GSE31798: DNA copy number profiles of NSCLC tumors GSE31799: Gene expression profiles of NSCLC tumors Refer to individual Series

2011-09-11 | E-GEOD-31800 | biostudies-arrayexpress

Intratumor heterogeneity of gene expression profiles in early stage non-small cell lung cancer (NSCLC)

Project description:Gene expression profiling of NSCLC tissues let to the establishment of several prognostic, predictive gene signatures with little overlap. To study factors introducing variability into gene expression microarray studies we compared interpatient (patient-to-patient) and intrapatient (tumor sub-sample) variations in gene expression profiles in stage I and II NSCLC tissues. We identified 128 probe sets which showed variable intratumoral expression Four different sites (A,B,C,D) of individual primary tumors and matched distant normal lung tissue (N) from 20 patients were used to establish gene expression patterns captured by Affymetrix HG-U133 Plus 2.0 arrays (n = 100).

2014-09-23 | E-GEOD-33532 | biostudies-arrayexpress

5q21 tiling array on prostate tumors

Project description:CGH profiles of prostate tumors on custom designed high resolution arrays tiling chromosome 5q21

2011-12-19 | GSE29228 | GEO