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Analysis of peripheral blood transcript and protein expression across adult systemic lupus erythematosus (SLE) and adult dermatomyositis (DM) patients, each compared to respective healthy matched control subjects.

ABSTRACT: The study interrogates SLE and DM gene expression measurements across three platforms: Affymetrix transcriptomics, SomaLogic proteomics, and Rules Based Medicine (RBM) proteomics. Patients are matched 1:1 with healthy donor subjects by age, ethnicity, and sex. DM patients are matched 1:3 with SLE patients by the same criteria. All patients have been treated for at least one year, and represent patients receiving standard treatment care for the respective diseases. The data posted contain SLE patients in support of the paper Distinct Interferon and Intracellular Signaling Signatures in Systemic Lupus Erythematosus and Dermatomyositis by Integrative Transcriptomic and Proteomic Analysis. Dermatomyositis (DM) patient consent requires controlled access, as a result the equivalent DM data are deposited in dbGaP Study Accession phs003270.v1.p1.

ORGANISM(S): Homo sapiens

PROVIDER: GSE318067 | GEO | 2026/02/06

REPOSITORIES: GEO

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