Tumor cytokine profiles in a radioresistant TC-1 mouse model treated with IL-7 and radiotherapy

ABSTRACT: Cytokine and chemokine expression profiles were generated to characterize treatment- and radioresistance-associated differences in the tumor microenvironment of a TC-1 mouse model. Using parental TC-1 and radiation-resistant TC-1/IR tumors established in syngeneic mice, cytokine protein profiling was performed on tumor lysates following different treatment conditions, including radiotherapy, IL-7–based immune modulation, and their combination. This dataset enables comparative analysis of intratumoral cytokine landscapes across resistance status and treatment modalities in an in vivo setting.

ORGANISM(S): Mus musculus

PROVIDER: GSE318153 | GEO | 2026/01/31

REPOSITORIES: GEO