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Lineage-Specific Oncogenic Reprogramming of COL17A1 Orchestrates a Pro-Invasive and Hypoxia-Adapted Niche in HNSC

ABSTRACT: Head and Neck Squamous Cell Carcinoma (HNSC) originates from specialized epithelium, and identifying lineage-specific oncogenes is crucial for understanding tumor progression. In this study, we identified COL17A1 as a potential core regulator in HNSC. To characterize the transcriptional landscape and molecular mechanisms regulated by COL17A1, we performed bulk RNA-sequencing on the human oral squamous cell carcinoma cell line, SAS. We compared the gene expression profiles of control cells (transfected with negative control siRNA) against COL17A1-depleted cells (transfected with COL17A1-specific siRNAs). This dataset reveals that depletion of COL17A1 leads to the dismantlement of a specific "Partial-EMT" gene module and induces a metabolic shift, highlighting its role in maintaining the malignant phenotype of HNSC cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE318280 | GEO | 2026/02/11

REPOSITORIES: GEO

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