Mechanisms of the antiproliferative effects of SIRT6 inhibition in melanoma: A multi-omics analysis [RNA-Seq A375]

ABSTRACT: Melanoma is one of the deadliest types of skin cancer due to its ability to metastasize if not treated early. While targeted- and immune- therapies have significantly improved melanoma treatment outcomes, acquired drug resistance even with combined therapeutics remain prevalent. SIRT6 is a nuclear histone deacetylase that regulates DNA repair, metabolism, and chromatin remodeling. It is overexpressed in melanoma and its inhibition in melanoma is known to have anti-proliferative response, and alterations in pathways related to cell cycle, senescence, and metastasis.In this study we utilized RNA sequencing, proteomics, and Ingenuity Pathway Analysis on genetically modified human melanoma cells to determine the downstream mechanism of SIRT6 in melanoma.

ORGANISM(S): Homo sapiens

PROVIDER: GSE318337 | GEO | 2026/03/04

REPOSITORIES: GEO