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Single-cell transcriptomic landscape of epithelial heterogeneity in metastatic hormone-naïve prostate cancer

ABSTRACT: Single-cell transcriptomic profiling was performed on diagnostic prostate biopsy specimens from patients with metastatic hormone-naïve prostate cancer to characterize epithelial tumor heterogeneity at diagnosis. Integrated and case-specific analyses revealed that tumors are composed of heterogeneous epithelial cell populations, including basal-associated and epithelial–mesenchymal transition–related transcriptional states, in addition to conventional luminal epithelial cells. No discrete epithelial cluster with high expression of canonical neuroendocrine markers was detected at baseline. These data provide a single-cell–level resource describing epithelial transcriptional states in treatment-naïve metastatic prostate cancer.

ORGANISM(S): Homo sapiens

PROVIDER: GSE318581 | GEO | 2026/02/05

REPOSITORIES: GEO

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