Genome-wide maps of TCF7L1 binding during early adipogenesis

ABSTRACT: Here we show through genome-wide binding studies that transcription factor 7-like 1 (TCF7L1) represses structure-related genes during adipogenesis. Intriguingly, TCF7L1 is induced in a cell contact-dependent manner by confluency in preadipocytes and is required for adipocyte differentiation by repressing transcription of cell structure genes. TCF7L1 is also sufficient to bestow adipogenic potential upon non-adipogenic cells. These results implicate TCF7L1 as a novel adipogenic competency factor that uniquely determines adipogenic fate through cell structure organization required for adipocyte gene activation.

ORGANISM(S): Mus musculus

PROVIDER: GSE31867 | GEO | 2011/09/02

SECONDARY ACCESSION(S): PRJNA145073

REPOSITORIES: GEO