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Transcriptomic profiling of AC16 cardiomyocytes under TPEN-induced zinc deficiency

ABSTRACT: Zinc deficiency is an important risk factor for myocardial injury, yet the underlying cytoprotective mechanisms remain incompletely understood. In this study, bulk RNA sequencing was performed in human AC16 cardiomyocytes treated with the zinc chelator TPEN or vehicle control to characterize transcriptional changes induced by zinc deficiency. Differential expression and pathway enrichment analyses revealed activation of apoptosis- and stress-related pathways, providing a transcriptomic framework for subsequent mechanistic investigations of ATF3-mediated mitochondrial and survival signaling.

ORGANISM(S): Homo sapiens

PROVIDER: GSE318912 | GEO | 2026/03/30

REPOSITORIES: GEO

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