The APC/C subunit APC7 promotes hepatocellular carcinoma progression by mediating ubiquitination and degradation of LATS1/2 to activate YAP/TAZ

ABSTRACT: Introduction: The anaphase-promoting complex/cyclosome (APC/C) is a multi-subunit E3 ubiquitin ligase critically involved in cell cycle regulation. However, the pathological functions of its individual subunits, particularly in hepatocellular carcinoma (HCC), remain largely unexplored. Objectives: To systematically analyze the expression and prognosis of APC/C in pan-cancer, and also focus on studying the function and mechanism of APC7 in the progression of HCC.

ORGANISM(S): Homo sapiens

PROVIDER: GSE319107 | GEO | 2026/05/15

REPOSITORIES: GEO