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White adipose tissue from aP2-Pex5 knockout and control mice

ABSTRACT: These arrays contain data from gonodal adipose tissue of aP2-Pex5 -/- male mice

ORGANISM(S): Mus musculus

PROVIDER: GSE31940 | GEO | 2012/03/01

SECONDARY ACCESSION(S): PRJNA145017

REPOSITORIES: GEO

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White adipose tissue from aP2-Pex5 knockout and control mice

Project description:These arrays contain data from gonodal adipose tissue of aP2-Pex5 -/- male mice 4 arrays from gonadal adipose tissue from control mice (Swiss background) are compared with 4 arrays from gonadal adipose tissue of aP2-Pex5 knockout mice. The latter lack functional peroxisomes in adipose tissue.

2012-03-01 | E-GEOD-31940 | biostudies-arrayexpress

Transcription profiling of mouse adipose tissue of lipodystrophic aP2-nSREBP1c trangenic animals

Project description:Identifying gene expression changes in adipose tissue of lipodystrophic aP2-nSREBP1c trangenic mice Experiment Overall Design: RNA from epididymal white adipose pads of three 10-week-old aP2-nSREBP1c transgenic males and three litter-matched WT controls was analyzed by MOE430v2.0 GeneChipâ¢ arrays, one mouse per array.

2008-06-17 | E-GEOD-9130 | biostudies-arrayexpress

adipose tissue Glut4 overexpression or knockout

Project description:The goal of this study is to determine the effects of adipose-specific Glut4 overexpression or knockout on changes in adipose tissue global gene expression Three mice from each of four genotypes were studied using a total of 12 microarray chips: aP2-Cre transgenic mice (controls for adipose-Glut4-/- mice), adipose-Glut4-/- mice; FVB mice (littermate controls for adipose-GLUT4-Tg mice) and adipose-GLUT4-Tg mice with Glut4 transgenically overexpressed under the control of the aP2 promoter. Total RNA from perigonadal adipose tissue was extracted using the RNeasy Mini Kit from Qiagen. Affymetrix gene chip hybridization and analysis were performed at the Genomics Core Facility of the Beth Israel Deaconess Medical Center.

2012-01-28 | E-GEOD-35378 | biostudies-arrayexpress

RNA-Sequencing analysis of adipose tissue from obese WT mice and AP2-Cre MCT1 knockout mice

Project description:Adipose tissue is an active producer of lactate. In obesity, the increased size of adipocytes is accompanied by an increase in lactate production in adipose tissue, caused by hypoxia in obese adipocytes. How lactate affects metabolism in adipocyte and insulin sensitivity remains unclear. Here we develop a mouse model of MCT1,coding by Slc16a1, specific deletion in adipose tissues, using the AP2 promoter to drive Cre expression. This MCT1 AKO mice develop more severe insulin resistance in obesity with 16 weeks high fat diet treatment, while few changes happen to lipid metabolism in adipose tissues. We used RNA-seq to analyze the gene expression patterns of eWAT of obese MCT1 AKO mice compared to WT, and found significant changes in innate immune signaling and adipocyte apoptosis that reflect systemic inflammation and insulin resistance.

2021-10-01 | GSE184760 | GEO

Transcription profiling of mouse white adipose tissue from PPARb/d knockout

Project description:Analysis of white adipose tissue of PPARb/d knockout mice. Data may point towards putative target genes of PPARb/d and thus the function of PPARb/d in white adipose tissue. Datasets were used to identify glycogen synthase 2 as novel PPAR target. Experiment Overall Design: Three month old male PPARb/d knock-out mice were on a mixed background (Sv129/C57BL/6). Wild-type littermates served as control animals. Animals received standard chow. Epididymal white adipose tissue (WAT) was removed and total RNA was isolated and pooled afterwards (five animals per group). Pooled RNA was hybridized to Affymetrix mouse genome 430 2.0 arrays arrays. Five microgram total RNA was labeled according to the ENZO-protocol, fragmented and hybridized according to Affymetrix protocols.

2008-06-16 | E-GEOD-8344 | biostudies-arrayexpress

aP2-nSREBP1c_white_Adipose_Tissue_expression_differentials

Project description:Identifying gene expression changes in adipose tissue of lipodystrophic aP2-nSREBP1c trangenic mice Keywords: Genetic modification

2007-09-22 | GSE9130 | GEO

Effect PPARb/d knockout in white adipose tissue

2007-07-04 | GSE8344 | GEO

TP53INP2 knockout in inguinal white adipose tissue

Project description:Excessive fat accumulation is a major risk factor for the development of type 2 diabetes.To determine the mechanisms by wich TP53INP2 regulates adipogenesis, gene expression profile was performed in inguinal white adipose tissue fromTP53INP2-deficient mice.

2018-04-03 | GSE103586 | GEO

TP53INP2 knockout in perigonadal white adipose tissue

Project description:Excessive fat accumulation is a major risk factor for the development of type 2 diabetes.To determine the mechanisms by wich TP53INP2 regulates adipogenesis, gene expression profile was performed in perigonadal white adipose tissue fromTP53INP2-deficient mice.

2018-04-03 | GSE103585 | GEO

Alox5 Knockout Signature in Mouse White Adipose Tissue

Project description:The purpose of this experiment was to determine the murine white adipose expression traits that were changed in response to knocking Alox5 out. Keywords: gene specific knockout signature

2007-02-17 | GSE7026 | GEO

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