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Epigenetic approaches by analysis of circulating miRNAs and global DNA methylation in veterinarians occupationally exposed to volatile anesthetics

ABSTRACT: Occupational exposure to waste anesthetic gases (WAGs) in veterinary operating rooms represents a potential health concern due to limited environmental monitoring. In this study, plasma samples from veterinarians chronically exposed to isoflurane and sevoflurane and from matched unexposed controls were analyzed to investigate molecular alterations associated with WAG exposure. Circulating microRNA expression was profiled using the NanoString nCounter® Human v3 miRNA Expression Assay. Differential expression analysis was performed to identify miRNAs associated with occupational exposure. Additional bioinformatic analyses were conducted to explore the potential biological pathways related to the identified miRNAs.

ORGANISM(S): Homo sapiens

PROVIDER: GSE319599 | GEO | 2026/03/19

REPOSITORIES: GEO

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