Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Prefrontal cortex bulk RNA-seq analysis of drug-treated Tbr1+/K228E heterozygous mice at P40

ABSTRACT: Autism spectrum disorder (ASD) affects approximately 2.8% of the population and is characterized by substantial genetic heterogeneity. Bulk RNA sequencing was performed on prefrontal cortex tissue from Tbr1+/K228E heterozygous (HT) and wild-type (WT) mice. Animals were analyzed at postnatal day 40 (P40) following three weeks of treatment with fluoxetine or lithium. Both male and female mice were included. Dissected prefrontal cortex tissue was used for RNA extraction and sequencing.

ORGANISM(S): Mus musculus

PROVIDER: GSE319620 | GEO | 2026/07/28

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Prefrontal cortex bulk RNA-seq analysis of drug-treated Adnp heterozygous mice at P40

Project description:Autism spectrum disorder (ASD) affects approximately 2.8% of the population and is characterized by substantial genetic heterogeneity. Bulk RNA sequencing was performed on prefrontal cortex tissue from Adnp heterozygous (HT) and wild-type (WT) mice. Animals were analyzed at postnatal day 40 (P40) following three weeks of treatment with fluoxetine or lithium. Both male and female mice were included. Dissected prefrontal cortex tissue was used for RNA extraction and sequencing.

2026-07-28 | GSE319615 | GEO

Prefrontal cortex bulk RNA-seq analysis of drug-treated Dyrk1a+/I48X heterozygous mice at P40

Project description:Autism spectrum disorder (ASD) affects approximately 2.8% of the population and is characterized by substantial genetic heterogeneity. Bulk RNA sequencing was performed on prefrontal cortex tissue from Dyrk1a+/I48X heterozygous (HT) and wild-type (WT) mice. Animals were analyzed at postnatal day 40 (P40) following three weeks of treatment with fluoxetine or lithium. Both male and female mice were included. Dissected prefrontal cortex tissue was used for RNA extraction and sequencing.

2026-07-28 | GSE319616 | GEO

Prefrontal cortex bulk RNA-seq analysis of drug-treated PTEN KI heterozygous mice at P40

Project description:Autism spectrum disorder (ASD) affects approximately 2.8% of the population and is characterized by substantial genetic heterogeneity. Bulk RNA sequencing was performed on prefrontal cortex tissue from PTEN KI heterozygous (HT) and wild-type (WT) mice. Animals were analyzed at postnatal day 40 (P40) following three weeks of treatment with fluoxetine or lithium. Both male and female mice were included. Dissected prefrontal cortex tissue was used for RNA extraction and sequencing.

2026-07-28 | GSE319618 | GEO

Transcriptome analysis in the prefrontal cortex of Tbr1+/K228E heterozygous mice treated with drug

Project description:Autism spectrum disorders (ASD) affect ~2.8% of the population, but the underlying biological mechanisms remain poorly understood, largely due to significant genetic heterogeneity. Mouse models have identified numerous candidate mechanisms; however, whether these can be grouped into functionally coherent subtypes remains unclear, limiting targeted, mechanism-based treatments. We analyzed prefrontal cortex transcriptomes from 17 distinct ASD mouse models, encompassing both sexes, under baseline and two separate drug-treatment conditions, totaling 1,008 mice across 204 groups.

2026-07-28 | GSE293704 | GEO

Analysis of TBR1 downnstream target genes in embryonic forebrains

Project description:TBR1 is a forebrain specific T-box transcription factor. Tbr1-/- mice have been characterized by defective axonal projections from cerebral cortex and abnormal neuronal migration of cerebral cortex and amygdala. To investigate how TBR1 regulates neural development, the gene expression profile of Tbr1-/- brains was compared with WT littermates. Total RNAs purified from forebrains at embryonic day 16.5 were hybridized on Affymetrix microarrays

2013-12-31 | E-GEOD-49237 | biostudies-arrayexpress

Analysis of TBR1 downnstream target genes in embryonic forebrains

2013-12-31 | GSE49237 | GEO

Tbr1 regulates regional and laminar identity of postmitotic neurons in developing neocortex

Project description:Areas and layers of the cerebral cortex are specified by genetic programs that are initiated in progenitor cells and then, implemented in postmitotic neurons. Here, we report that Tbr1, a transcription factor expressed in postmitotic projection neurons, exerts positive and negative control over both regional (areal) and laminar identity. Tbr1 null mice exhibited profound defects of frontal cortex and layer 6 differentiation, as indicated by down-regulation of gene-expression markers such as Bcl6 and Cdh9. Conversely, genes that implement caudal cortex and layer 5 identity, such as Bhlhb5 and Fezf2, were up-regulated in Tbr1 mutants. Tbr1 implements frontal identity in part by direct promoter binding and activation of Auts2, a frontal cortex gene implicated in autism. Tbr1 regulates laminar identity in part by downstream activation or maintenance of Sox5, an important transcription factor controlling neuronal migration and corticofugal axon projections. Similar to Sox5 mutants, Tbr1 mutants exhibit ectopic axon projections to the hypothalamus and cerebral peduncle. Together, our findings show that Tbr1 coordinately regulates regional and laminar identity of postmitotic cortical neurons. Mouse E14.5 neocortices and Postnatal day (P) 0.5 brains: E14.5 neocortices KO, 3; E14.5 neocortices WT, 3; Postnatal day (P) 0.5 brains frontal WT, 4; Postnatal day (P) 0.5 brains frontal KO, 4; Postnatal day (P) 0.5 brains parietal WT, 4; Postnatal day (P) 0.5 brains parietal KO, 4; Postnatal day (P) 0.5 brains occipital WT, 4; Postnatal day (P) 0.5 brains occipital KO, 4.

2010-07-27 | E-GEOD-22371 | biostudies-arrayexpress

Tbr1 regulates regional and laminar identity of postmitotic neurons in developing neocortex

2010-07-27 | GSE22371 | GEO

Juvenile fluoxetine evoked gene expression changes in the rat medial prefrontal cortex

Project description:To understand the consequences of chronic exposure to fluoxetine during juvenile life on global transcriptional changes withing the rat medial prefrontal cortex in adulthood. To understand the consequences of chronic exposure to fluoxetine during juvenile life on global transcriptional changes withing the rat medial prefrontal cortex in adulthood.

2024-06-30 | GSE270731 | GEO

Postnatal fluoxetine evoked gene expression changes in the rat medial prefrontal cortex

Project description:To understand the consequences of chronic exposure to fluoxetine during postnatal life on global transcriptional changes withing the rat medial prefrontal cortex in adulthood. To understand the consequences of chronic exposure to fluoxetine during postnatal life on global transcriptional changes withing the rat medial prefrontal cortex in adulthood.

2024-06-30 | GSE270730 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data