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Tet2 deficiency alters CD4+ T-cell function and promotes T-cell lymphoma with a TFH-cell immunophenotype.

ABSTRACT: TET2 mutations are frequent in TFH derived lymphomas, but how epigenetic disruption initiates malignant T cell transformation is unclear. We performed CRISPER mediated TET2-knockout in normal human CD4+ T cells and culture them long term. We perfromed scRNAseq after 40 or 90 days or long-term culture (>200 days). ScRNA-seq revealed a persistent proliferative cluster characterized by elevated stem like transcriptional features compared to wild type counterparts

ORGANISM(S): Homo sapiens

PROVIDER: GSE319667 | GEO | 2026/03/26

REPOSITORIES: GEO

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