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Screen glycosyltransferase ST6GalNAc2 KO mice and B4GalNT1/B4GalNT2 double KO mice relative to C75 Wild Type controls

ABSTRACT: The purpose of this experiment is to respond to the NIGMS mandate to screen Core F generated glycosyltransferase KO mice in Core E and Core C. The goal is to screen several tissues for gene expression changes in ST6GalNAc2 KO mice and B4GalNT1/B4GalNT2 double KO mice relative to C75 Wild Type controls. Tissues for Core E analysis were selected by mining public databases including the NIH GEO database for tissues that expressed the KO genes at moderate to high levels.

ORGANISM(S): Mus musculus

PROVIDER: GSE31993 | GEO | 2011/09/08

SECONDARY ACCESSION(S): PRJNA145167

REPOSITORIES: GEO

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Screen glycosyltransferase ST6GalNAc2 KO mice and B4GalNT1/B4GalNT2 double KO mice relative to C75 Wild Type controls

Project description:The purpose of this experiment is to respond to the NIGMS mandate to screen Core F generated glycosyltransferase KO mice in Core E and Core C. The goal is to screen several tissues for gene expression changes in ST6GalNAc2 KO mice and B4GalNT1/B4GalNT2 double KO mice relative to C75 Wild Type controls. Tissues for Core E analysis were selected by mining public databases including the NIH GEO database for tissues that expressed the KO genes at moderate to high levels. Results from Core E gene expression analysis are then used to help Core C select tissues to follow up with glycan analysis on in each of the KO mice. For the ST6GalNAc2 KO mouse we selected: Brain, Small Intestine, Lymph Node and Thyroid for analysis. For the B4GalNT1/B4GalNT2 double KO mouse we selected: Kidney, Mammary Gland, Thymus and Testes for analysis. Wild type tissues were analyzed in parellel.

2011-09-07 | E-GEOD-31993 | biostudies-arrayexpress

Expression data from testis of two-month-old WT and Ccnyl1 KO mice

Project description:Ccnyl1 is a newly identified genes, but the founction of which remained unclear, here we used the Ccnyl1 knockout mice to finding clues for its functional roles We used microarrays to screen the expression differences of genes in testis of WT and Ccnyl1 KO mice We used testis tissues from two month old mice, which were of adult age, and two mice per group

2015-03-30 | E-GEOD-67391 | biostudies-arrayexpress

Glycosyltransferase Extl1 promotes CCR7-mediated dendritic cell migration to restrain infection and autoimmunity [WT vs. KO]

Project description:Purpose: mRNAs sequencing of the gene expression differences in CCR7L-stimulated Extl1-dificient mDC and wild-type mDC. The goals of this study are to investigate the biological effect of glycosyltransferase Extl1 in regulating dendritic cell function.

2023-01-19 | GSE184861 | GEO

Mus musculus

Project description:Screen glycosyltransferase ST6GalNAc2 KO mice and B4GalNT1/B4GalNT2 double KO mice relative to C75 Wild Type controls

| PRJNA145167 | ENA

Lysosome-enriched fractions from the liver of Cln8 KO mice and WT mice

Project description:Lysosome-enriched fractions from the liver of Cln8 KO mice and WT mice. Included are four datasets: 1. Lysosome-enriched fraction from the liver of Cln8 KO mice, replicate 1 (CLN8_KO_1). 2. Lysosome-enriched fraction from the liver of Cln8 KO mice, replicate 2 (CLN8_KO_2). 3. Lysosome-enriched fraction from the liver of WT mice, replicate 1 (WT_1). 4. Lysosome-enriched fraction from the liver of WT mice, replicate 2 (WT_2).

| MSV000082938 | MassIVE

Gene Expression in d5 wound-edge tissues of MFG-E8 WT and MFG-E8 KO mice

Project description:Gene Expression in d5 wound-edge tissues of MFG-E8 WT and MFG-E8 KO mice Affymetrix GeneChipÂ® Mouse Genome 430 array was used to study the gene expression in d5 wound-edge tissues of MFG-E8 WT and MFG-E8 KO mice Gene Expression in d5 wound-edge tissues of MFG-E8 WT and MFG-E8 KO mice

2016-07-21 | E-GEOD-73229 | biostudies-arrayexpress

Expression data from testis of two-month-old WT and Ccnyl1 KO mice

2015-03-30 | GSE67391 | GEO

Gene Expression in d5 wound-edge tissues of MFG-E8 WT and MFG-E8 KO mice

Project description:Gene Expression in d5 wound-edge tissues of MFG-E8 WT and MFG-E8 KO mice Affymetrix GeneChip® Mouse Genome 430 array was used to study the gene expression in d5 wound-edge tissues of MFG-E8 WT and MFG-E8 KO mice

2016-07-21 | GSE73229 | GEO

Murine liver tissues: WT and Wip1 KO mice after Partial Hepatectomy at 24h and 36 h.

Project description:Transcriptional profiling of mouse liver tissues comparing Wild type liver tissues with Wip1 KO mice liver tissues after Partial Hepatectomy at 24h and 36 h. WT vs. Wip1 KO tissues after Partial Hepatectomy at 24h and 36 h .

2014-07-03 | E-GEOD-59023 | biostudies-arrayexpress

Profiling liver from 5LO KO and WT B6 mice

Project description:To understand the effects of knocking out the 5-LO gene on gene expression in key metabolic target tissues liver. The 5LO KO mouse liver profiling data was analyzed by identifying genes that were up- and down-regulated at selected p value and fold change in the liver of 5LO KO mice compared to the corresponding WT B6 controls.

2013-03-22 | E-GEOD-38081 | biostudies-arrayexpress

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