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Distinct Stemness Programs and PD-1 Responsiveness of Progenitor Exhausted CD8+ T Cells between Chronic Viral Infection and Tumor

ABSTRACT: We reported the CD8+ T cell exhaustion differences between chronic viral infection and tumor regarding their transcriptomic and epigenetic landscapes, immune checkpoint blockade responsiveness and underlying molecular mechanisms by using single-cell RNA-seq.

ORGANISM(S): Mus musculus

PROVIDER: GSE320007 | GEO | 2026/02/24

REPOSITORIES: GEO

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Disease-specific exhaustion features and PD-1 immunotherapy responsiveness of antigen-specific CD8+ T cells at single-cell resolution [scRNA-seq]

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