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Expression data from 293T cell treated with ROCK inhibitor

ABSTRACT: We used microarray to determine the genes whose expression was changed at three or six hours after Y27632 treatment.

ORGANISM(S): Homo sapiens

PROVIDER: GSE32024 | GEO | 2014/04/21

SECONDARY ACCESSION(S): PRJNA147519

REPOSITORIES: GEO

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Expression data from 293T cell treated with ROCK inhibitor

Project description:We used microarray to determine the genes whose expression was changed at three or six hours after Y27632 treatment. Three-condition experiment; 293T control vs 293T treated with Y27632 for three hours, 293T control vs 293T treated with Y27632 for six hours.

2014-04-21 | E-GEOD-32024 | biostudies-arrayexpress

Expression levels of mature miRNAs from Huh7 cell treated with ROCK inhibitor

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Expression data from β-globin let7 HeLa tet off cells treated with doxycycline

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Data on differentially expressed proteins in rock inhibitor-treated human trabecular meshwork cells using SWATH-based proteomics.

Project description:Rho-associated coiled coil-forming protein kinase (ROCK) inhibitors represent a novel class of anti-glaucoma drugs because of their ocular hypotensive effects. However, the underlying mechanisms responsible for lowering intraocular pressure (IOP) are not completely clear. The protein profile changes in primary human trabecular meshwork (TM) cells after two days treatment with a ROCK inhibitor were studied using label-free SWATH acquisition. These results provided significant data of key protein candidates underlying the effect of ROCK inhibitor. Using the sensitive label-free mass spectrometry approach with data-independent acquisition (SWATH-MS), we established a comprehensive TM proteome library. All raw data generated from IDA and SWATH acquisitions were uploaded and published in the Peptide Atlas public repository (http://www.peptideatlas.org/) for general release (Data ID PASS01254).

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Regulation of gene expression upon inhibition of ROCK and MLCK in mammary epithelial cells

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Gene expression changes upon treatment of T47D breast cancer cells with the Pan-PI3 kinase inhibitor GDC-0941

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