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Influenza virus infection-induced gene expression changes of regional B cells are mediated in part through type I IFN

ABSTRACT: Influenza virus infection-induced gene expression changes of regional B cells are mediated at least in part through type I Interferon: Our objective is to determine whether the influenza virus-infection induced gene expression changes in regional lymph node B cells are facilitated at least in part through type I interferon. Our specific aim is to compare the gene expression profile of highly FACS-purified B cells in the regional lymph nodes of wildtype and IFNR-/- mice prior to and 48h following infection with influenza virus infection and to contrast this expression profile with that of FACS-purified wildtype B cells activated in vitro with IFN-beta +/- anti-CD86 for 12h. Keywords: Infection-induced responses

ORGANISM(S): Mus musculus

PROVIDER: GSE3203 | GEO | 2006/08/26

SECONDARY ACCESSION(S): PRJNA92871

REPOSITORIES: GEO

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Transcription profiling of mouse influenza virus infected in wild type and mutant animals revels induced gene expression changes of regional B cells are mediated in part through type I IFN

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