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Spatial transcriptomics analysis of dual-pathway spots

ABSTRACT: It is generally accepted that hepatic gluconeogenesis is active in the fasted state and inactive in the fed state. In contrast, de novo lipogenesis is active in the fed state and is inactive in the fasted state. We report a subset of periportal spots (hepatocytes) in spatial transcriptomics that are positive of both transcriptionally gluconeogenic and de novo lipogenic.

ORGANISM(S): Mus musculus

PROVIDER: GSE320372 | GEO | 2026/04/10

REPOSITORIES: GEO

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Identification of a novel subset of hepatocytes that are simultaneously gluconeogenic and de novo lipogenic in the fed state and are naturally insulin resistant

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