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MDA-MB-231 cell: infected with lentivirus to stably express mut-Elf5 vs WT-Elf5

ABSTRACT: Elf5 induced transcriptional changes in MDA-MB-231 origin, control (mut Elf5) vs WT ELF5

ORGANISM(S): Homo sapiens

PROVIDER: GSE32144 | GEO | 2012/09/20

SECONDARY ACCESSION(S): PRJNA154953

REPOSITORIES: GEO

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MDA-MB-231 cell: infected with lentivirus to stably express mut-Elf5 vs WT-Elf5

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Transcript Profiling of Elf5+/- Mammary Glands During Pregnancy Identifies Novel Targets of Elf5

Project description:Elf5, an epithelial-specific Ets transcription factor, plays a crucial role in the pregnancy-associated development of the mammary gland. However, the molecular mechanisms employed by Elf5 to exert its effects on the mammary gland are largely unknown. Transcript profiling was used to investigate the transcriptional changes that occur as a result of Elf5 haploinsufficiency. We show that the development of the Elf5+/- gland is delayed at a transcriptional and morphological level, due to the delayed increase in Elf5 protein in these glands. We also identify a number of potential Elf5 target genes, including Mucin 4, whose expression, is directly regulated by the binding of Elf5 to an Ets-binding site within its promoter. We identify novel transcriptional targets of Elf5 and show that Muc4 is a direct target of Elf5, further elucidating the mechanisms through which Elf5 regulates proliferation and differentiation in the mammary gland.

2010-09-27 | GSE23373 | GEO

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