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Single-neuron sequencing of PBN-projecting Sp5C neurons in CION or Sham mice

ABSTRACT: Parabrachial (PBN)-projecting the caudal part of spinal trigeminal nucleus (Sp5C) neurons are essential for trigeminal neuralgia-induced pain hypersensitivity, but the molecular identities of PBN-projecting Sp5C neurons remain unclear. We have employed single-neuron sequencing by Smart-seq3 to study PBN-projecting Sp5C neurons in chronic constriction injury of the infraorbital nerve(CION）model or Sham mice. This study suggest that the Tac1 gene serve as a specific marker for PBN-projecting Sp5C neurons and demonstrate transcriptional reprogramming induced by CION in PBN-projecting Sp5C Tac1 neurons.

ORGANISM(S): Mus musculus

PROVIDER: GSE322600 | GEO | 2026/03/07

REPOSITORIES: GEO

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