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RNA-seq analysis of carbon framework-mediated metabolic reprogramming in senescent cells: effects of C3N nanosheets and photoactivation

ABSTRACT: This RNA-seq dataset investigates the senolytic effects of carbon nitride quantum dots (C3N QDs) combined with irradiation on senescent human umbilical vein endothelial cells (HUVECs). The study compares three experimental conditions: senescence alone (S), senescence treated with C3N QDs (S+C), and senescence treated with C3N QDs followed by irradiation (S+C+I). Transcriptomic profiling revealed that the combined treatment (S+C+I) significantly reprogrammed gene expression patterns associated with aging and inflammation. Specifically, the S+C+I group showed a notable upregulation of genes such as MAPT, FOXO4, and PTEN, while markedly downregulating key senescence-associated secretory phenotype (SASP) factors including IL6, CXCL8, SERPINE1, and TERT compared to the S group. These data provide comprehensive insights into the molecular mechanisms by which C3N QDs-mediated photoactivation alleviates cellular senescence and suppresses pro-inflammatory pathways.

ORGANISM(S): Homo sapiens

PROVIDER: GSE322654 | GEO | 2026/03/04

REPOSITORIES: GEO

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