A Positive Feedback Loop Between TKT and c-Myc Drives TACE Resistance In Hepatocellular Carcinoma
Ontology highlight
ABSTRACT: Hepatocellular carcinoma (HCC) often receives transarterial chemoembolization (TACE), yet clinical benefit is limited by resistance driven by ischemia-induced adaptations. This study explains how transketolase (TKT) in the pentose phosphate pathway (PPP) modulates HCC progression and TACE refractoriness, and clarifies its mechanistic connection to oncogenic signaling.
ORGANISM(S): Homo sapiens
PROVIDER: GSE322668 | GEO | 2026/03/07
REPOSITORIES: GEO
ACCESS DATA