Celastrol induces autophagy and apoptosis of human osteosarcoma cells via downregulation PI3K/Akt/mTOR signaling pathway

ABSTRACT: Celastrol, a terpenoid compound isolated from the plant Tripterygium wilfordii (Thunder God Vine), has been shown to have powerful anti-tumor effects against various developing cancers. Osteosarcoma is the most common primary bone malignancy in children and adolescents, and its long-term survival has remained stagnant over the past few decades.

ORGANISM(S): Homo sapiens

PROVIDER: GSE324043 | GEO | 2026/03/11

REPOSITORIES: GEO