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Xenium single cell spatial transcriptomics from patient-derived glioblastoma organoid cultured on brain slice and a primary glioblastoma sample

ABSTRACT: Glioblastoma shows marked spatial heterogeneity and hypoxia-associated signaling. Here, we performed probe-based Xenium single-cell spatial transcriptomics on a primary human glioblastoma sample and on a patient-derived glioblastoma organoid cultured on a brain slice. The aim was to assess the in situ single-cell expression of hypoxia-related genes, with a particular focus on VEGFA and CXCL12. These datasets provide spatially resolved transcriptomic information to study hypoxic niches and tumor microenvironmental interactions in glioblastoma.

ORGANISM(S): Homo sapiens

PROVIDER: GSE324268 | GEO | 2026/03/17

REPOSITORIES: GEO

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