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Bioinspired, Mitochondria-targeted Single-atom Nanozyme Enhances Bone Regeneration by Reprogramming Stem Cell Energy Metabolism

ABSTRACT: A bioinspired nanozyme—TPP-DMSN-Fe/Cu—mimics mitochondrial complex IV and targets mitochondria to regulate cellular energy metabolism. This approach markedly boosts bone regeneration in vivo, as demonstrated by enhanced bone volume and mineral density in critical-sized bone defects rat models. The study opens new avenues for mitochondria-targeted therapies in bone repair.

ORGANISM(S): Mus musculus

PROVIDER: GSE324502 | GEO | 2026/03/16

REPOSITORIES: GEO

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Bioinspired, Mitochondria-targeted Single-atom Nanozyme Enhances Bone Regeneration by Reprogramming Stem Cell Energy Metabolism

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