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Effect of L-PGDS loss on cellular response during cuprizone induced demyelination

ABSTRACT: L-PGDS is a secretory oligodendrocyte protein; we aimed to determine how the loss of this protein affected the transcriptome of different cell populations during demyelination. We found that very distinct changes in the microglial transcriptome following L-PGDS loss. Specifically, these microglia adopt an aged, dysfunctional gene signature characterized by the increase in ribosomal genes.

ORGANISM(S): Mus musculus

PROVIDER: GSE324634 | GEO | 2026/03/20

REPOSITORIES: GEO

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