Nimbolide competitively binds to 14-3-3 epsilon with TFEB to promote lipophagy and ameliorate atherosclerosis

ABSTRACT: Atherosclerosis is a chronic inflammatory disease driven by lipid accumulation in the arterial wall, where macrophage foam cell formation represents a key pathological event. Nimbolide (NIM), a natural limonoid with documented anti-inflammatory and lipid-regulatory properties, may offer therapeutic potential, though its effects on atherosclerosis remain poorly characterized.

ORGANISM(S): Homo sapiens

PROVIDER: GSE325316 | GEO | 2026/03/24

REPOSITORIES: GEO