MUC21 is downregulated in oral squamous cell carcinoma and associated with poor prognosis

ABSTRACT: The role of MUC21 in oral squamous cell carcinoma (OSCC) remains unexplored. Microarray data of 10 paired OSCC and adjacent normal oral mucosae (para-OSCC) from this study and datasets from GEO and TCGA RNA-seq were analyzed to screen out differentially expressed genes including MUC21 which was further validated by qRT-PCR. the impact of expression changes of MUC21 on OSCC was retrospectively studied by clinical data, MUC21 immunohistochemistry data from a cohort of patients. In vitro OSCC cell lines experiments were also conducted to further verify the results.

ORGANISM(S): Homo sapiens

PROVIDER: GSE325374 | GEO | 2026/03/24

REPOSITORIES: GEO