RNA-seq analysis of human NSCLC cell lines treated with 9α,11α-dihydroxy-kaurenoic acid (AL-X)

ABSTRACT: Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality worldwide. In this study, we performed bulk RNA sequencing to investigate the transcriptomic effects of 9α,11α-dihydroxy-kaurenoic acid (9α,11αOH-KA, also referred to as AL-X) in human NSCLC cells. A549, HCC827, and H1975 cell lines were treated with 10 μg/mL 9α,11αOH-KA or vehicle (DMSO) for 48 hours. Total RNA was extracted and subjected to paired-end sequencing using the Illumina platform. This dataset provides a comprehensive resource for understanding the molecular mechanisms underlying mitochondrial dysfunction and anti-cancer effects induced by 9α,11αOH-KA in NSCLC.

ORGANISM(S): Homo sapiens

PROVIDER: GSE325732 | GEO | 2026/03/23

REPOSITORIES: GEO