Single-cell RNA sequencing (scRNA-seq) of murine mesenchymal stromal cells (MSCs) under cardiac stress induced by transverse aortic constriction.

ABSTRACT: We performed scRNA-seq using the 10x Genomics platform to investigate how cardiac stress influences the transcriptional profiles of female murine MSCs. MSCs were isolated from bone marrow of control (sham-operated) and mice subjected to transverse aortic constriction (TAC) for four weeks. Comparative analysis of single-cell transcriptomes was conducted to identify stress-induced alterations in MSC states.

ORGANISM(S): Mus musculus

PROVIDER: GSE326121 | GEO | 2026/06/06

REPOSITORIES: GEO