Transcriptomics

Dataset Information

0

Major functional transcriptome of an inferred center regulator of an ER(-) breast cancer model system


ABSTRACT: We aimed to find clinically relevant gene activities ruled by the signal transducer and activator of transcription 3 (STAT3) proteins in an ER(-) breast cancer population via network approach. STAT3 is negatively associated with both lymph nodal category and stage. MYC is a component of STAT3 network. MYC and STAT3 may co-regulate gene expressions for Warburg effect, stem cell like phenotype, cell proliferation and angiogenesis. We identified a STAT3 network in silico showing its ability in predicting its target gene expressions primarily for specific tumor subtype, tumor progression, treatment options and prognostic features. The aberrant expressions of MYC and STAT3 are enriched in triple negatives (TN). They promote histological grade, vascularity, metastasis and tumor anti-apoptotic activities. VEGFA, STAT3, FOXM1 and METAP2 are druggable targets. High levels of METAP2, MMP7, IGF2 and IGF2R are unfavorable prognostic factors. STAT3 is an inferred center regulator at early cancer development predominantly in TN.

ORGANISM(S): Homo sapiens

PROVIDER: GSE32641 | GEO | 2012/09/25

SECONDARY ACCESSION(S): PRJNA146971

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2012-09-25 | E-GEOD-32641 | biostudies-arrayexpress
2010-11-04 | GSE24124 | GEO
2015-02-05 | E-GEOD-52798 | biostudies-arrayexpress
2021-02-02 | GSE165205 | GEO
2010-03-03 | E-GEOD-15904 | biostudies-arrayexpress
2015-02-05 | GSE52798 | GEO
2023-10-11 | GSE245066 | GEO
2023-10-11 | GSE245064 | GEO
2017-02-17 | GSE81381 | GEO
2022-08-26 | GSE212076 | GEO