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NAT10-mediated N4-acetylcytidine modification drives RNA splicing of PML to alleviate adipose-derived stem cell senescence and promote diabetic wound healing

ABSTRACT: Cellular senescence in adipose-derived stem cells (ADSCs) limits their application in diabetic wounds. Alternative splicing generates multiple isoforms that play critical roles in modulating stem cell senescence. N-acetyltransferase 10 (NAT10) regulates N4-acetylcytidine (ac4C) modification, which has been implicated in RNA splicing. As the role of NAT10 in ADSCs remains elusive, this study aimed to investigate the function of NAT10 in ADSC senescence and RNA splicing.

ORGANISM(S): Homo sapiens

PROVIDER: GSE326590 | GEO | 2026/04/06

REPOSITORIES: GEO

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