Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

The immune landscape of the post–cardiac arrest brain in young and aged mice

ABSTRACT: The objective of the current study was to profile immune cells in the post-cardiac arrest brain of young and aged mice at single-cell resolution.

ORGANISM(S): Mus musculus

PROVIDER: GSE326906 | GEO | 2026/07/29

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

The immune landscape of the post–cardiac arrest brain in young and aged mice

Project description:The immune landscape of the post–cardiac arrest brain in young and aged mice

| PRJNA1447928 | ENA

Young and aged mouse bladders

Project description:Young and aged mouse bladders

| PRJNA629290 | ENA

Characterization of young and aged lung tissue RNA 60 days post-influenza infection

Project description:To identify molecular characteristics of young and aged lungs post-influenza infection, we isolated RNA from lungs 60 days post-infection and examined by bulk RNAseq. We found a large number of genes remain upregulated in aged compared to young lungs. Comparison with expression of immune system-related genes from Nanostring expriments indicated this was largely infection-induced rather than baseline differences between age. This indicates that aged lungs fail to return to homeostasis following a viral respiratory infection

2020-10-06 | GSE159066 | GEO

Aged vs Young Camk2a+ Neuron Proteome

Project description:Comparison of aged and young Camk2a+ neuronal proteome by transduction of mice with AAV-Camk2a;PheRS+ followed by AzF administration for BONCAT labeling of neuronal proteomes.

2025-11-07 | PXD057488 | Pride

sperm proteome of aged and young males

Project description:we build the sperm proteome profile of aged and young males

| PXD035466 |

scRNAseq of spleen and atherosclerotic plaques from young and aged healthy and young and aged atherosclerotic mice

Project description:T cells change substantially with age and are involved in atherosclerosis. Aging is the strongest clinical risk factor for atherosclerosis so we profiled T cells in young and aged mice prior to atherosclerosis (healthy) and in young and aged atherosclerotic mice (diseased).

2023-08-22 | GSE210719 | GEO

Aged, Young and Restored Samples from Mobilized Peripheral Blood [mRNA]

Project description:We report the gene expression changes in mobilized peripheral blood in aged, young, and aged/young samples cocultured in transwell. Restored samples refer to aged MPB co-cultured with young MPB in the transwell culture

2021-12-01 | GSE138563 | GEO

Aged, Young and Restored Samples from Mobilized Peripheral Blood [miRNA]

Project description:We report the miRNA expression in each CD34+ cells and their exosomes in mobilized peripheral blood in aged, young, and aged/young samples cocultured in transwell. Restored samples refer to aged MPB co-cultured with young MPB in the transwell culture.

2021-12-01 | GSE138564 | GEO

Differentiation of young and replicatively aged mouse C2C12 muscle cells

Project description:Age-related impairments in myoblast differentiation may contribute to reductions in muscle function in older adults but the underlying proteostasis processes are not well understood. We investigated young (P6-10) and replicatively aged (P48-50) C2C12 myoblast cultures during early (0h-24h) and late (72h-96h) stages of differentiation using deuterium oxide (D2O) labelling and mass spectrometry. The absolute dynamic profiling technique for proteomics (Proteo-ADPT) was used to quantify the absolute rates of abundance change, synthesis and degradation of individual proteins. Proteo-ADPT encompassed 116 proteins and 74 proteins exhibited significantly (P<0.05, FDR <5 %) different changes in abundance between young and aged cells at early and later periods of differentiation. Young cells exhibited a steady pattern of growth, protein accretion and fusion, whereas aged cells failed to gain protein mass or undergo fusion during later differentiation. Maturation of the proteome was retarded in aged myoblasts at the onset of differentiation, but the proteome appeared to ‘catch up’ with the young cells during the early differentiation period. However, this ‘catch up’ process in aged cells was not accomplished by higher levels of protein synthesis. Instead, a lower level of protein degradation in aged cells was responsible for the elevated gains in protein abundance. Our novel data point to a loss of proteome quality as a precursor to the lack of fusion of aged myoblasts and highlights dysregulation of protein degradation, particularly of ribosomal and chaperone proteins, as a key mechanism that may contribute to age-related declines in the capacity of myoblasts to undergo differentiation.

2023-06-27 | PXD029515 | Pride

Proteomics analysis of iWAT-EVs from young and aged mice

Project description:Proteomics analysis of iWAT-EVs to identify EV related markers in young and aged mice

2025-09-05 | PXD066710 | Pride