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Microarray analysis of liver-specific Sirt1 knockout mice lung tissue

ABSTRACT: To explore the pathology of liver-specific Sirt1 knockout mice. To specify, the liver-specific Sirt1 knockout mice commenced high blood glucose within three months. When the mice age extended to one year, the mice present surprising higher lung tumor vulnerabilities in contrast to wild type, we explore the underlying mechanism of the symptom

ORGANISM(S): Mus musculus

PROVIDER: GSE326924 | GEO | 2026/04/04

REPOSITORIES: GEO

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Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism

Project description:Hepatic metabolic derangements are key components in the development of fatty liver, insulin resistance, and atherosclerosis. SIRT1, a NAD+-dependent protein deacetylase, is an important regulator of energy homeostasis in response to nutrient availability. Here we demonstrate that hepatic SIRT1 regulates fatty acid metabolism by positively regulating PPAR-alpha. Hepatocyte-specific deletion of SIRT1 impairs PPAR-alpha signaling and decreased fatty acid beta-oxidation in the liver. When challenged with a high-fat diet, liver-specific SIRT1 knockout mice develop hepatic steatosis, hepatic inflammation, and endoplasmic reticulum stress. Taken together, our data indicate that SIRT1 plays a vital role in the regulation of hepatic lipid homeostasis.

2009-04-07 | GSE14921 | GEO

A SIRT1-centered Circuitry Regulates Breast Cancer Stemness and Metastasis

Project description:Deficiency of deacetylase SIRT1 or its downstream target PRRX1 promotes breast cancer stemness and metastasis. To explore the mechnisms of SIRT1 and its downstream target PRRX1 in breast cancer, we analysed the gene expressions in breast cancer BT549 cells with SIRT1 knockout or PRRX1 knockout or not.

2018-03-28 | GSE112365 | GEO

Microarray analysis of liver-specific Sirt1 knockout mice lung tissue

Project description:Microarray analysis of liver-specific Sirt1 knockout mice lung tissue

| PRJNA1447952 | ENA

Liver transcriptomic response to partial hepatectomy in intestinal-specific SIRT1 knockout mice

Project description:Liver regeneration following partial hepatectomy (PHx) requires coordinated metabolic and inflammatory responses. Here, we investigated the contribution of intestinal SIRT1 to hepatic transcriptional reprogramming during early regeneration. Intestinal-specific SIRT1 knockout mice (SIRTintKO) and wild-type (WT) littermates were subjected to PHx, and liver tissue was collected at 6 h and 24 h post-surgery. Bulk RNA sequencing was performed to characterize genotype- and time-dependent transcriptional changes. This dataset provides insight into gut–liver axis regulation of early regenerative priming and metabolic adaptation.

2026-04-28 | GSE328885 | GEO

The role of SIRT1 deacetylase in neuromuscular aging and amyotrophic lateral sclerosis

Project description:SIRT1 deacetylase functions in a variety of cells and tissues to mitigate age- and disease-induced damages. However, it remains unknown if SIRT1 also acts to prevent pathological changes that accrue in motor units, and specifically alpha-motor neurons, with advancing age and during the progression of amyotrophic lateral sclerosis (ALS). Here, we show that SIRT1 expression decreases in the spinal cord of wild type mice with advancing age. Using mouse models that overexpress or inactivate SIRT1 in motor neurons, we discovered that SIRT1 prevents age-related degeneration of motor neurons’ presynaptic sites at neuromuscular junctions (NMJs). We also found that increasing SIRT1 in motor neurons delays degeneration of presynaptic sites at NMJs and extends the lifespan of SOD1G93A mice. Thus, SIRT1 has a similar effect on aging and ALS-affected motor neurons, two conditions in which a remarkable number of transcripts are similarly altered in the spinal cord. These include genes involved in inflammatory and immune responses and genes with known function at synapses. These findings show that SIRT1 functions to mitigate pathological changes induced by aging and ALS, two conditions with a surprising degree of overlap in the spinal cord.

2018-12-11 | GSE106803 | GEO

RNAseq in Sirt1 wild-type or deleted mouse T-ALLs

Project description:C57BL6 mice harboring Sirt1 conditional knockout NOTCH1-HDDPEST-induced leukemias were treated with vehicle (control) or tamoxifen to induce isogenic deletion of Sirt1. Here we report the gene expression profile of leukemic blasts obtained from the spleen from control- or tamoxifen-treated leukemic mice.

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A therapeutically targetable NOTCH1-SIRT1-KAT7 axis in T-ALL

Project description:C57BL6 mice harboring Sirt1 conditional knockout NOTCH1-DE-induced leukemias were treated with vehicle (control) or tamoxifen to induce isogenic deletion of Sirt1. Here we report the H4K12ac ChIP-seq epigenetic profile of leukemic blasts obtained from the spleen from control- or tamoxifen-treated leukemic mice.

2022-12-08 | GSE203386 | GEO

Role of SIRT1 in diet-induced metabolic diseases

Project description:The purpose of this study is to investigate the role of SIRT1 in high-fat diet-induced liver steatosis and insulin resistance. SIRT1 is a nuclear enzyme that could remove an acetyl-group from target proteins by using NAD as co-substrate. Homologs of this protein in yeast and the roundworm C. elegans are able to delay the aging process in response to nutrients. However, the molecular mechanism by which SIRT1 sense the environment to mediate this response are poorly understood. We have shown that when chronically fed with a 40%-fat diet, SIRT1 heterozygous animals gain significantly more weight compared to wild type littermates. They are also hyperinsulimia, more insulin-resistant, and accumulate more lipids in liver. Interestingly, these animals also show signs of premature aging, such as an early appearance of gray fur, defective motor activity, and decreased fertility. In this microarray study, we analyzed the gene expression profiles in the liver of WT low-fat diet, Het low-fat diet, WT high-fat diet, and Het high-fat diet using Agilent Whole Genome Mouse 4x44 multiplex format oligo arrays following the Agilent-1-color microarray-based gene expression analysis protocol. This microarray analysis concluded that SIRT1 Het mice reponsed to the high-fat diet differently from the WT control mice. Liver total RNAs from SIRT1 WT and Het mice that were fed with either a low-fat diet or a high-fat diet for 34 weeks were used for a microarray gene expression study. Three biological replicates for each group were used.

2012-07-31 | E-GEOD-39778 | biostudies-arrayexpress

Liver transcriptomic response to partial hepatectomy in intestinal-specific SIRT1 knockout mice

Project description:Liver transcriptomic response to partial hepatectomy in intestinal-specific SIRT1 knockout mice

| PRJNA1456950 | ENA

RNAseq in Sirt1 wild-type or conditional KO mouse T-ALLs

Project description:C57BL6 mice harboring Sirt1 conditional knockout NOTCH1-DE-induced leukemias were treated with vehicle (control) or tamoxifen to induce isogenic deletion of Sirt1. Here we report the gene expression profile of leukemic blasts obtained from the spleen from control- or tamoxifen-treated leukemic mice.

2022-12-08 | GSE203387 | GEO

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