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Chromatin accessibility profile at single cell level of different phenotypic tumors derived from the human non-muscle invasive bladder carcinoma cell line, MGH-U3

ABSTRACT: To understand the genetic mechanisms by which IGFBP5 regulates aggressive progression and squamous traits, we performed whole-exome sequencing (WES) on three distinct cell lines: CTR-MGH-U3-LT, UCSD-MGH-U3-LT, and MP-MGH-U3-LT. WES revealed no mutations in IGFBP5, suggesting that its regulatory role may involve epigenetic mechanisms. We next sought to perform single-cell ATAC-seq to investigate a potential epigenetic mechanism underlying IGFBP5 regulated squamous traits and aggressiveness.

ORGANISM(S): Homo sapiens

PROVIDER: GSE326929 | GEO | 2026/04/07

REPOSITORIES: GEO

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