Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Temporal Uncoupling of Radial Glial Progenitor Cell Lineage Progression in Self-organizing Organoid System

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE327470 | GEO | 2026/06/29

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Temporal Uncoupling of Radial Glial Progenitor Cell Lineage Progression in Self-organizing Organoid System – MADM-CloneSeq

Project description:Radial glial progenitors (RGPs) produce all excitatory neurons in the developing cerebral cortex. Mosaic Analysis with Double Markers (MADM)-based lineage tracing in vivo revealed a quantitative framework of RGP lineage progression. Here we established MADM technology in embryonic stem cells to probe RGP lineage progression in self-organizing cortical organoid system. We found that RGPs exhibit high level of equipotency in organoid rather than temporally stereotyped lineage progression as observed in vivo. RGPs in organoids showed increased lineage restriction, diminishing cell-type diversity in clones of cortical projection neurons, despite uniform RGP scRNAseq transcriptional signatures and unitary lineage trajectory. Hence, critical non-cell-autonomous cues absent in self-organizing systems and/or genuine stem cell niche are essential for faithful RGP lineage progression and the generation of cortical cell-type diversity.

2026-06-29 | GSE327468 | GEO

Temporal Uncoupling of Radial Glial Progenitor Cell Lineage Progression in Self-organizing Organoid System – mTmG scRNA-Seq

2026-06-29 | GSE326044 | GEO

Temporal Uncoupling of Radial Glial Progenitor Cell Lineage Progression in Self-organizing Organoid System

Project description:Temporal Uncoupling of Radial Glial Progenitor Cell Lineage Progression in Self-organizing Organoid System

| PRJNA1450976 | ENA

Temporal Uncoupling of Radial Glial Progenitor Cell Lineage Progression in Self-organizing Organoid System – MADM-CloneSeq

Project description:Temporal Uncoupling of Radial Glial Progenitor Cell Lineage Progression in Self-organizing Organoid System – MADM-CloneSeq

| PRJNA1451059 | ENA

Temporal Uncoupling of Radial Glial Progenitor Cell Lineage Progression in Self-organizing Organoid System – mTmG scRNA-Seq

Project description:Temporal Uncoupling of Radial Glial Progenitor Cell Lineage Progression in Self-organizing Organoid System – mTmG scRNA-Seq

| PRJNA1443219 | ENA

Radial Glial Lineage Progression and Differential Intermediate Progenitor Amplification Underlie Striatal Compartments and Circuit Organization.

Project description: Not available

| S-EPMC6094944 | biostudies-literature

Direct and indirect neurogenesis from radial glial progenitor cell clones in the mouse neocortex.

Project description: Not available

| S-EPMC12759082 | biostudies-literature

Reelin induces a radial glial phenotype in human neural progenitor cells by activation of Notch-1.

Project description: Not available

| S-EPMC2447831 | biostudies-literature

Prospective isolation of functionally distinct radial glial subtypes - lineage and transcriptome analysis

Project description:Since the discovery of radial glia as the source of neurons, their heterogeneity in regard to neurogenesis has been described by clonal and time-lapse analysis in vitro. However, the molecular determinants specifying neurogenic radial glia differently from radial glia that mostly self-renew remain ill-defined. Here, we isolated two radial glial subsets that co-exist at mid-neurogenesis in the developing cerebral cortex and their immediate progeny. While one subset generates neurons directly, the other is largely non-neurogenic but also gives rise to Tbr2-positive basal precursors, thereby contributing indirectly to neurogenesis. Isolation of these distinct radial glia subtypes allowed determining interesting differences in their transcriptome. These transcriptomes were also strikingly different from the transcriptome of radial glia isolated at the end of neurogenesis. This analysis therefore identifies, for the first time, the lineage origin of basal progenitors and the molecular differences of this lineage in comparison to directly neurogenic and gliogenic radial glia.

2008-05-29 | GSE8034 | GEO

Restoration of the defect in radial glial fiber migration and cortical plate organization in a brain organoid model of Fukuyama muscular dystrophy.

Project description: Not available

| S-EPMC8487058 | biostudies-literature