Pristimerin enhances erastin-induced ferroptosis in AML cells via the ATF3/SLC7A11 axis

ABSTRACT: Acute myeloid leukemia (AML) is a highly aggressive hematologic malignancy predominantly seen in adults, with chemotherapy remaining the primary modality for its clinical management. Nevertheless, the efficacy of chemotherapy is often compromised by issues such as drug resistance, toxicity, and long-term adverse effects, particularly in refractory and relapsed patients. Natural products have historically served as a vital source for the development of anti-cancer agents.

ORGANISM(S): Homo sapiens

PROVIDER: GSE327625 | GEO | 2026/04/15

REPOSITORIES: GEO