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A CSF Disease-Associated Macrophage Signature defines Progressive Multiple Sclerosis

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE328265 | GEO | 2026/05/17

REPOSITORIES: GEO

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A CSF Disease-Associated Macrophage Signature defines Progressive Multiple Sclerosis [Fresh]

Project description:Objective: Progression in multiple sclerosis (MS) often corresponds to irreversible disability in MS patients. Cellular changes in the cerebrospinal fluid (CSF) have provided biomarkers and mechanisms in relapsing-remitting MS (RRMS) but remain understudied in primary and secondary progressive MS (summarized herein as PMS). Methods: We combined retrospective flow cytometry of CSF cells from RRMS (n = 169), PMS (n = 56), and non-inflammatory controls (n = 74) with prospective CSF single-cell transcriptomics of 35 individuals (11 controls, 12 RRMS, and 12 PMS) and with confirmatory CSF ELISA. Available CSF single cell data from age-matched and Alzheimer’s disease served as additional controls. Results: Proportions of CD14+ monocytes in CSF are increased in PMS and correlated with clinical surrogate markers of progression. Transcriptionally, these monocytes resembled border-associated macrophages (BAM)-like cells with a chronically activated antigen-presenting phenotype. Additionally, these monocytes shared some features with disease-associated microglia/macrophages (DAM), previously identified in neurodegeneration. Induction of DAM-associated molecules, including transcribed and soluble TREM2, was unique to SPMS and supported its differential diagnosis. Interpretation: We thus identified MS stage-specific CSF signatures and shared cellular features of degeneration detectable in CSF of PMS patients.

2026-05-17 | GSE328264 | GEO

A CSF Disease-Associated Macrophage Signature defines Progressive Multiple Sclerosis [Frozen]

2026-05-17 | GSE327243 | GEO

A CSF Disease-Associated Macrophage Signature defines Progressive Multiple Sclerosis

Project description:A CSF Disease-Associated Macrophage Signature defines Progressive Multiple Sclerosis

| PRJNA1454431 | ENA

A CSF Disease-Associated Macrophage Signature defines Progressive Multiple Sclerosis [Frozen]

Project description:A CSF Disease-Associated Macrophage Signature defines Progressive Multiple Sclerosis [Frozen]

| PRJNA1450035 | ENA

A CSF Disease-Associated Macrophage Signature defines Progressive Multiple Sclerosis [Fresh]

Project description:A CSF Disease-Associated Macrophage Signature defines Progressive Multiple Sclerosis [Fresh]

| PRJNA1454458 | ENA

Mapping the Molecular Signature of Progressive Multiple Sclerosis

Project description:This SuperSeries is composed of the SubSeries listed below.

2025-02-26 | GSE290554 | GEO

Progressive multiple sclerosis

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-06-20 | GSE231587 | GEO

Progressive multiple sclerosis

Project description:Progressive multiple sclerosis

| PRJNA966951 | ENA

CSF inflammatory biomarkers responsive to treatment in progressive multiple sclerosis capture residual inflammation associated with axonal damage.

Project description: Not available

| S-EPMC6212343 | biostudies-literature

Mapping the Molecular Signature of Progressive Multiple Sclerosis [194017]

Project description:Multiple Sclerosis is a complex neurological disorder characterised by inflammation, demyelination, and neurodegeneration of the central nervous system. While treatments exist for relapsing-remitting multiple sclerosis, therapeutic options for the progressive forms remain limited, highlighting the need to understand their distinct pathological mechanisms. To identify subtype specific molecular signatures in patients with multiple sclerosis, bulk RNA sequencing was performed in 90 brain tissue samples from donors with relapsing-remitting, secondary progressive, and primary progressive multiple sclerosis, as well as controls without the disease. This study provides open access to transcriptomic data from multiple sclerosis tissue samples, enabling other researchers to perform independent analyses, validate findings, and generate new hypotheses.

2025-02-26 | GSE290450 | GEO

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